Is it expected that Pyston play well with numpy/scipy? This is the biggest barrier that I see towards adoption of PyPy for numerical computing. If Pyston can work with numpy and scipy then it would be a huge accomplishment.
Their focus is on getting the dropbox application working under pyston. It would probably take contributions from someone outside of dropbox to make this a reality. Presumably it will be easier on pyston than with pypy since pyston has designed in better compatibility with the CPython C API.