From a practical perspective, Clojure is pretty close to Python in day to day usage. The largest difference to adapt to for me (and a couple others that I worked with), was the absence of the imperative-style for loop/yield keyword combination in Python. To get something similar, you tend to need to rewrite into something with lazy-seq/loop+recur. Everything else (for work doing web development, data processing, and internal API development) is pretty close with favorable points to each depending on the task.

If you were already writing pure functions in python and then creating data flows using generator expressions or list comprehensions, moving to Clojure is very natural. If you aren't, and if your job is to move bits from one place to another performing transformations along the way, you were already having issues in Python and might want to consider the approach regardless of the particular language employed.