Django does dominate the Python web framework world. Flask does pretty well as a microframework runner up.

Methinks someone who left Python in 2002 is out of touch. ;-)

I would say Django (framework) and Flask (microframework) are the biggest. But lots of people build many mainly due to the WSGI support that makes it easy.

At first, I actually thought this post was about a PHP microframework called Flight: https://github.com/mikecao/flight