> how can one definitely opine on the safety of them
Because the statistics still include all those variations. The variations are also not that huge, and are also independently studied.
You might as well ask how we can talk about the risk/safety of general anesthesia, given that different hospitals and even different anesthesiologists use different drugs.
Because the statistics still include all those variations. The variations are also not that huge, and are also independently studied.
You might as well ask how we can talk about the risk/safety of general anesthesia, given that different hospitals and even different anesthesiologists use different drugs.