Yeah you can, there's packages like xremap and input-remapper where you can define custom keyboard re-mappings. To replicate the Emacs key bindings from macOS, you can bind Ctrl+F to right arrow, Ctrl+E to End, etc. I even re-binded Cmd+C to Ctrl+C so I didn't lose any muscle memory from years of macOS shortcuts. Obviously requires some upfront time but once you get it working it works very well in my experience (and the keyboard re-mappings work at the input event level, so it works across all applications automatically).