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Yes. Some brains react to some stimulants differently. That's the whole reason ADHD can be treated with Adderall.


This isn't true, it affects everyone the same way. But you could say the optimal dosage is different for different people.

I think people just like saying this because they're afraid stimulants will get banned otherwise.


That's wildly inaccurate. A brain is a complex system with emergent properties that result in us. The basic effect is an increase in Norepinephrine interactions but the effect that has on people with ADHD is obviously very different.

It's like saying that engines with fuel and engines with no fuel respond the same way to adding fuel: it increases the length of time they will run.

Stop adding fuel and the resulting system behaviour will be quite different.


> The basic effect is an increase in Norepinephrine interactions but the effect that has on people with ADHD is obviously very different.

I've heard it described as a difference in magnitude. If a person with ADHD has an arbitrary "focus" score of 5/10, and a normal person has a focus score of 8/10. If a stimulant brings them both up to a score of 9/10, then the effects may appear more noticeable in the ADHD person because a 4 point jump is typically far more apparent than a 1 point jump.


I’ve seen friends with stimulant and can say with full confidence they are not reacting to them the way I am. They’re « high », ideas everywhere and nowhere, acting like their overstimulated, full of energy… when I’m quieter, energy level normal, can think at one thing at a time without switching… and sleeping under the effect is not an issue. I a have great nap.

So no. Maybe if I try a récréative drug will I have my adhd multiplied, but here it’s not. I think it should have been fun while younger discovering that amphetamine could quiet me when everyone was dancing under the influence.

It’s not perfect. No medication are. If you abuse it, take it without need… yeah it can be abused. Don’t try heart medication either. Or lithium for kicks. Or…


> I’ve seen friends with stimulant and can say with full confidence they are not reacting to them the way I am.

That means very little. Do you think all people react the same way to all medications? If someone takes an SSRI and it doesn't work, then does that mean they do not have depression, anxiety, or whatever the medication is indicated for? Do opioids only work for people with chronic pain?

As someone with ADHD, it's extremely common for people with ADHD to think they are some sort of rare subspecies of humans where everything different in their life is due to ADHD. In all aspects of life, people with ADHD are far closer to normal than they might want to believe. It's why people even doubt the existence of ADHD at times. I've yet to see anyone seriously doubt the existence of Schizophrenia, for example.


All drugs affect everyone differently. Something that's ok with you can literally kill someone else - simple example - smoking weed with someone that has some lung disease.

That's why just having them illegal makes them 100x more dangerous. Through less knowledge among users, no guidance on packaging and difficult to identify the substance if someone had to be taken to the hospital.


Literally not true. There are clear, reproducible, and obvious differences in brain chemistry between people.


> This isn't true, it affects everyone the same way.

Adderall causes me to be essentially unable to move or function. When I tried it, I was very hungry but I couldn't get myself out of bed to get food so I had to sleep it off! Pure dextroamphetamine works a treat for me though.


this is true. Regular people get hyperfocus and adhd people get focus. real adhd is a neurologic disorder. its an instability in the flow of dopamin. so adderall puts dopamin flow on 200% and suddenly there is a steady flow for adhd people.

there are maybe 10% of people getting not focused and awake of adderal.

But "adhd brain reacts different then regular brain" is not true. For both its 20x dopamin release in 8 hours.




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