Isn't DXM a disassociative at high doses? Moreover, don't people risk getting quite addicted to it, escalating their dose beyond even what you take? Perhaps your dose is stable, but even optimistically, it is management, not a cure. A cure is more possible with lower doses of DXM before it becomes a hard dependence.
The bupropion (Wellbutrin) portion of the combination mentioned above serves as a CYP2D6 inhibitor as well, actually boosting the action of the DXM in the body. Auvelity dosing starts lower with just 45mg of DXM, jumping to 90mg as the tolerance curve starts to set in.
CYP2D6 metabolizes DXM into a much more potent NMDA antagonist (dextrorphan, sometimes abbreviated to DXO). Inhibiting it boosts some action(s) of DXM but likely reduces the NMDA antagonist effect.
