It's weird that there's no mention of adrenaline (epinephrine) and noradrenaline (norepinephrine). Dopamine is only a precursor for a broader chemical reaction. All three - with dopamine - play crucial roles in our bodies' stress response system, and definitely with fear reactions. Dopamine is just a neurotransmitter.
> Dopamine is only a precursor for a broader chemical reaction.
No, dopamine is a signaling molecule that participates directly in this functionality.
You're right that it's just a neurotransmitter, but the relative pathways about how they're produced are irrelevant for this study. They looked at how dopamine binds to certain receptors in certain parts of the brain under certain conditions.
OK, maybe not "just a precursor" but still "just a neurotransmitter".
I've read "The Molecule of More" and as much reasonably looking material I could find on the subject to "understand" my ADHD and fight it w/o meds. And I still feel dumb. Could you please explain how dopamine "participates directly in this functionality"?
FTA: “The team showed that indeed they express “D1” receptors for the neuromodulator. Commensurate with the degree of dopamine connectivity“
There are receptors specifically for dopamine on the amygdala neurons. Dopamine molecules are released by the pre-synaptic neurons, travel across the synapse, and bind to these receptors.
Dopamine’s role in the nervous system is not simply an intermediate on the pathway to produce epinephrine or norepinephrine. If you thought like this you’d reach the conclusion that testosterone is simply a precursor to estrogen because the pathway to convert it exists in some tissues of the body.
You’re not dumb, it’s an incredibly complex topic with convoluted and contradictory messaging everywhere.
The way that I’ve learned to think about it is that the brain is made up neurons, and they perform specific functions, technically individually but more usefully understood in regional groupings (primarily figured out via fMRI/blood flow studies and lesion experiments).
Each neuron’s activity is regulated by specific neurotransmitters, and the type of receptors expressed in neurons also correlates with these functional areas (figured out through PET/radio-tagged molecule scans and biopsies). Regarding dopamine specifically, the area that is responsible for effortful attention (prefrontal cortex) as well as for reward (in a general sense, broader “good” not only simpler treats) processing (nucleus accumbens) have high concentrations of dopamine receptors.
Therefore, drugs that interact with dopamine receptors or with chemical chains that involve dopamine can affect these functions.
Neurotransmitters are just chemicals and they go through many complex and interrelated metabolic chains, and at baseline (in a typical individual, barring specific genetic differences) it is often most useful to assume they’re all there and instead understand where they’re used.
This comment might not be the most succinct and I’m just started my education on the subject so I’m sure there are inaccuracy’s and I’d be happy if they’re pointed out, but I do hope that it helps you get a somewhat clearer picture and realize that you’re not dumb for being confused about this.
I gotta say that since doing beta blocker enhanced therapy I've basically wrapped up any emotional response to past trauma and can examine all that stuff fully without having to protect myself. Pretty great stuff.
