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My brother's family has done something similar although in a different direction. They have been strictly carnivore for several years now. Able to eat large amounts of food while keeping calories low and feeling satiated. It's worked well for them.

I'll look at that study you mentioned, thank you.



leptin deficiency is rare, so supplementation does not produce an effect in most people.

https://www.nejm.org/doi/full/10.1056/NEJM199909163411204

There is more information about the family involved out there, but I can't remember where I read about it.

A thing I found interesting about the genetics of hunger, is the concept of mongenetic, v polygenetic traits Monogenetic traits - a variation in a single gene is has an observed often severe impact. Polygenetic traits - variations in a large number of genes and environmental are contributing In reality these traits exist on a spectrum of severity. The more sublte the impact of a gene the more people you need to study to tease out the influence of the gene, so monogenetic traits tend to be discovered first.




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