You no longer run for VP. In the modern era the presidential candidate just chooses who they want.

By "run" I just meant that he'd appear in the set of people that might be considered (by Biden) if for any reason it turns out he wants Harris replaced.

Then go up to my first reply. Newsom isn't going to run for a position he has a 0% chance of winning and will piss people off trying. He probably wants a cabinet position.

I guess that would make sense, but what cabinet position would he actually want (and see as a stepping stone for later)? Secretary of State?

State would make a lot of sense.

I guess it would have the benefit of giving him exposure, and I'm not sure if there's a better cabinet position otherwise, but does being secretary of state actually help with making a case for people to like him for presidency? How much of the credit does he get if things go well vs. the blame if things go poorly?