Yes you can. Our site uses Jumpstart (lovely app) and we use Avo everyday with it.
Avo was designed to be unopinionated. I know that might sound off. Avo has a DSL, it must be opinionated, and it is with that DSL, but with the rest, we'd like to allow the developer to use what they want.
BYOB.
Bring your own authentication. You might not want to use devise, but something else. Avo enables you to add your own auth layer.
Bring your own search. Avo plays well with ransack, but you can hook into it and do your thing with algolia or something else.
Bring your own layer of multi tenancy. Scope things out as much as you need it. We have a customer that runs three platforms in one app using Avo. Believe me when I say they were able to scope out their data "to the bone".
So yeah. Avo plays amazingly well with existing apps. It was designed that way.