Maybe. On one hand USPS might have a database of which buildings are multi-family homes and reject stuff like "unit 123" if it's not a multi-family/tenant building. However, I've also seen letters addressed to "basement" (for someone who's renting out the basement of a single family home) which seem to arrive fine so maybe they're not doing too aggressive filtering.
https://www.usps.com/business/web-tools-apis/