I've never made it enough of a habit to feel like I've had long-lasting changes, but I do have one friend with serious life-long depression, who has approached psilocybin use methodically, as a means of treatment along with periodic ketamine dosing, and it seems to be working quite well. However, I'm not sure about long-lasting effects after quitting these drugs entirely. There are so many life-factors influencing 'depression'.
Everything is just strange when tripping, from the things you see to human interactions to life in general- whether the strangeness is beautiful or terrifying depends on the trip, but afterward it can have a lasting (at least long after the drug has worn off) child-like appreciation for things that might've been mundane, boring, or tedious. How long this break from monotony, or revitalization lasts, is hard to say.
Everything is just strange when tripping, from the things you see to human interactions to life in general- whether the strangeness is beautiful or terrifying depends on the trip, but afterward it can have a lasting (at least long after the drug has worn off) child-like appreciation for things that might've been mundane, boring, or tedious. How long this break from monotony, or revitalization lasts, is hard to say.