If you throw 100M people at this as a solution, do you expect to see most carefully and successfully getting through it like you or would most just become addicted and eventually lose their job and go homeless?
When it comes to something like Ayahuasca, I make a point of not recommending it. I lean into the woo of it, and allow "the ready people" to help realize their calling to it through me. I know, bear with me, but advocating something this wildly, impossibly potent and transformative is something I cannot do, and so I defer to greater wisdom.
For small doses of psilocybin, it is - both in my experiences and in a lot of scientific contexts - considered very, very safe. Greater doses, 2.5 dry grams, you start to introduce risk triggering latent psycho-affective disorders.
For most people with common neurotic conditions, anxiety, depression, etc, it is very low risk. Out of 100M, I'd say .1% is at risk having a very negative experience due to significant, untreated issues like schizophrenia.
All of things things require support. Community, a guiding hand, will truly improve the outcome.
Addicted and losing your job because of psilocybin? I've not tried it myself, but many of my friends have, and anecdotally, none of them have (to my knowledge) ever even gotten to the point of it being a "habit".
I can't say the same for alcohol, cocaine, and even cannabis. I know people who have had problems with all of them.
Even Terence McKenna, who himself was likely part mushroom given how many he ingested, said time and time again that mushrooms are resistant to abuse. If you take a very high dose, the experience itself can be so difficult and wonderful, that the idea of doing that to yourself again starts to seem ridiculous. :)