Wow I've never seen such bloated python project before. It has 10 dependancies with 2 additional optional dependancies and the introduction/tutorial is absurdly overspecific.

The first example they use to describe the tool is:

> Cufflinks is a tool to assemble transcripts, calculate abundance and conduct a differential expression analysis on RNA-Seq data. his example shows how to create a typical Cufflinks workflow with Snakemake. It assumes that mapped RNA-Seq data for four samples 101-104 is given as bam files.

This is epitome of non-programmer programming, colour me disappointed.

And yet it's still less crufty than the "by hackers for hackers" GNU Automake and less over engineered than the "made by real professional programmers at a real big tech company" Luigi. Would love the hear if you have any suggestions for actual alternatives for doing this type of automation beyond what make can neatly deal with rather than just going "eww.. it has dependencies"; "eww.. it's made by bioinformaticists".