I expect weaponization of drugs from malicious governments will come in a far more effective fashion. There's no need for oppressive cops if you can simply drug your population. Not only wipe away their anxiety, but any concept of fight or flight (the root of anxiety disorders) whatsoever. Pair it with increasingly endless entertainment, plummeting testosterone levels, and a general effeminization of society and you'd never need concern yourself with losing your grasp on power.

In Brave New World, this was soma. "A gram is better than a damn."