If Scala and Clojure were my only options, I might have a look into that. But as far as I know, both version aren't production quality and I don't know anything about the whole infrastructure and as of yet, I don't have any projects at work or in private where interoperability with anything .NET related is an option.
If the prospect of using the JVM bothers you that much, then why not try Scala .NET or Clojure-CLR?