Last I used MacPorts I thought it was more separate from MacOS, installing its own components rather than using what comes with the operating system.

I preferred the MacPorts model, but when I used them both, there seemed to be a lot less support compared to Homebrew. When builds stop working, they seemed to be fixed in Homebrew before they were fixed in MacPorts, and Homebrew also seemed to have more current versions of most packages available.