Yup! In the exact same way that not many EU countries would realistically operate within 1 single country if they are VC funded. Just like EU VC funded companies, The african based companies inherently have to think on a global scale on the onset. Unlike in the US/China where it's okay to be US/China only
Why? $500,000 isn't too bad, if you only had to invest your share - which might only be $5,000. The numbers are smaller, but the percentages may be greater. The number of chances to invest may also be greater, as they will have fewer services already in place.
I don't see that they'd need to worry about international markets. At least not initially.