Is it a drawback? If your "compare to 0" is "are all bits the same", then it would be an advantage.
An asymmetric range is a "drawback" of two's complement. Is that a drawback?
It depends upon what your building blocks in the technology are. For example, we don't use J-K flip flops anymore because they are a pain to make and use when MOSFET's are your building blocks (J-K wants bipolars).
0000 0000 and 1111 1111