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I work in tech am i am depressed. I am unable to move and think, negative thoughts amplifying in my mind till i lose my ability to think. I've no motivation and energy, i don't even feel like eating.

Want to imagine how it feels? Think like a tube with end point A and B forming a closed loop with amplifier between these points and negative thoughts are injected into this closed loop, they amplify each time they pass through the loop and after suddenly nothing makes sense.

No talk therapies, workout, yoga doesn't work in this case! I tried all these popular cures fo depression.

I don't have any underlying trauma or abuse, i am not poor (who is poor in tech?) with fulfilling life and my life doesn't suck! I've a boyfriend who takes care of me, listens to everything i say and supportive family yet i couldn't get myself out of it.

I've tried amphetamine, it works for me but i figured amphetamine works by reving up the supply of dopamine and Norepinephrine.

I was sucidal, i overdosed on Amphetamine and nearly died.

Back from the hospital, i realized using amphetamine is a shotgun approach to my issue.

Since the probability of two things happening, like Norepinephrine deficiency and Dopamine deficiency is less than probability of one of the happening.

I went forward with my best guess that I've NE deficiency and i started taking selective Pure norepinephrine reuptake inhibitors (NERIs)

I managed to take enough dose to bridge the dificiency gap then using a spreadsheet, slowly lowered the doses over a span of 3 years in a hope that body would increase its own supply to normalize the level.

Now, i am no longer depressed.

This is after a depression lasting a decade. And local health authorities seem like they don't really wanna help you.


They're are clinics that administer mdma and psilocybin, they're know for basically resting the brains dopamine system https://medium.com/s/trips-worth-telling/i-reset-my-brain-wi...


Impressive job.

Medicine is sadly too focused about the average, if you fall off the side you'll have to walk the distance on your own. I think many (including me) have experienced that.

Good luck


An interesting route might be doing the wim hof method regarding upping your NE temporarily

https://m.youtube.com/watch?v=EWHRumILOOk

You can also email me for questions.

Full disclosure: I was a participant in one of the landmark studies on it: https://www.pnas.org/content/111/20/7379


i'm interested in this. do you have any other studies?


it's sad that this is a throwaway because i hope you see my comment. i suffer from the same every day and my life doesn't move. i want to die every day. please reach out with some sort of contact. im in toronto, i have no idea what clinics or doctors or what to visit, i've never been to a doctor. email is in profile, if anyone has any info i'd love to hear it.


I recommend that you first see any psychiatrist who has experience treating depression (ask your primary care provider for a referral or find one online). Think of depression like any serious medical condition; if you aren't satisfied with a given provider or approach, then explore others.


>if you aren't satisfied with a given provider or approach, then explore others.

part of the problem is determining this



Just sent you an email from jessica{something_secret}@gmail.com


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