> I wonder if there's a way to ease the difficulty by filling in 'correct' features of the guesses
Rather than allowing players to guess individual features, I opted for the "highlight" system where all hidden features that match your guessed protein's features get auto-revealed. This way, if you suspect a transmembrane protein, you can just guess a known transmembrane protein and see which features auto-reveal.
> it would have been interesting to sift through classes or cell types
You're welcome to suggest databases with good coverage over the proteome that I could use for these.
> I presume you're showing even the 'low confidence' portions of the predicted structure?
Yes, any residues in the files I fetch get rendered. I rank by coverage before fetching.
> You could also show the primary amino acid sequence too
Thank you. I started the development with the interface first, basically making a mockup of how the finished game should look like, and then prodding LLMs with a stick to make a backend that would support this interface without crashing.
Making a nice-looking web GUI without knowing relevant vocabulary was a very clunky process in comparison to code pipelines, basically just pasting screenshots into the chat window and asking LLMs to "line up stuff properly", which they still couldn't manage to do in places.
My dream is forming a team of Tetlock-style superbiologists who can identify gene names on sight like Rainbolt, beat prediction markets on shorting biotech stocks, and smell out pre-cancerous cells like it's the final round of amongus.
Hahahaa ... I kinda love this, along with humans who can sit at a piano and play a song they've only heard once, or cook a complicated dish they only tasted once. That seems like the great Turing test... zero-shot humans.
But seriously, there probably are a few people who can see genes from proteins like that, faster than a whole datacenter of GPUs. Putting together such a brain trust could be invaluable.
You can play more than once in the practice mode. It turns on after you complete the daily puzzle.
There's almost 20k entries in my human gene database. You can choose any of them as your guess, but the "gene of the day" is chosen from a subset that has decent 3D structure coverage (meaning, not falling back to alphafold2 for visualization).
How can I enable practice mode? I just see "Practice Mode OFF" on the right, but nothing to click on. Does practice mode have infinite hints and guesses? That would be nice for people like me who know very little about proteins.
After you finish the game, the "game over" screen will show you the "practice" button to try again with a different protein.
If you're interested to learn more about proteins, I suggest asking an in-browser LLM like Claude Chrome to play and explain its guesses at your preferred level of familiarity. https://claude.com/chrome
> I wonder if there's a way to ease the difficulty by filling in 'correct' features of the guesses
Rather than allowing players to guess individual features, I opted for the "highlight" system where all hidden features that match your guessed protein's features get auto-revealed. This way, if you suspect a transmembrane protein, you can just guess a known transmembrane protein and see which features auto-reveal.
> it would have been interesting to sift through classes or cell types
You're welcome to suggest databases with good coverage over the proteome that I could use for these.
> I presume you're showing even the 'low confidence' portions of the predicted structure?
Yes, any residues in the files I fetch get rendered. I rank by coverage before fetching.
> You could also show the primary amino acid sequence too
I'll consider it.